Photo of Lea Bogensperger

Lea Bogensperger

Postdoctoral Researcher in Video Understanding
Johnson & Johnson Innovative Medicine

Before joining Johnson & Johnson in September 2026, I was a postdoctoral researcher in the Krauthammer Lab at the Department of Quantitative Biomedicine, University of Zurich, where I worked on generative modeling for protein design and biomedical imaging.

I did my PhD at the Institute of Computer Graphics and Vision, Graz University of Technology, supervised by Prof. Thomas Pock, with Prof. Carola-Bibiane Schönlieb as external referee. I defended my thesis "Variational Methods in Imaging Meet Machine Learning" in June 2024. During my PhD I worked on inverse problems in medical imaging, bilevel optimization, and generative modeling using diffusion models and flow matching for image segmentation.

Research

I'm interested in generative modeling (flow matching, diffusion and energy-based models) and its applications in biomedicine, ranging from video understanding and cell morphology to protein fitness optimization and medical image analysis. I also have a strong background in variational methods and inverse problems in imaging.

Publications

* indicates equal contribution.

2026

Joint Flow Matching Enables Continuous Dose-Conditioned Cell Morphing

Lea Bogensperger, Manuela Merlo, Martin Baumgartner, Michael Krauthammer, Bernard Ciraulo

ECCV-W 2026 ECCV Workshop on BioImage Computing (BIC)

We introduce a joint flow matching approach for continuous, dose-conditioned prediction of cell morphology under compound treatment, rather than treating drug concentrations as discrete categories.

Generating Physically Consistent Molecules with Energy-Based Models

Christoph Griesbacher, Lea Bogensperger, Andreas Habring, Thomas Pock

NeurIPS 2026 Conference on Neural Information Processing Systems

We present EBMol, an energy-based model that learns atom-additive potentials for 3D molecule generation, ensuring physical consistency through the Boltzmann distribution and achieving state-of-the-art results on QM9 and GEOM-Drugs.

Repurposing Protein Language Models for Latent Flow-Based Fitness Optimization

Amaru Caceres Arroyo*, Lea Bogensperger*, Ahmed Allam, Michael Krauthammer, Konrad Schindler, Dominik Narnhofer

arXiv 2026 arXiv preprint

We present CHASE, a framework for direct high-fitness protein variant generation by training a conditional flow-matching model on compressed protein language model embeddings within a compact latent space.

Uncovering Cas9 PAM diversity through metagenomic mining and machine learning

Tao Fang*, Lea Bogensperger*, Lilith Feer, Ahmed Allam, Valentyn Bezshapkin, Zsolt Balázs, Christian von Mering, Shinichi Sunagawa, Michael Krauthammer, Gerald Schwank

Nat. Commun. 2026 Nature Communications

CRISPR-PAMdb, a large-scale database of Cas9 proteins and PAM profiles, is introduced alongside CICERO, a protein language model–based predictor that enables accurate PAM preference inference and broad exploration of PAM diversity for genome editing.

Understanding, Accelerating, and Improving MeanFlow Training

Jin-Young Kim, Hyojun Go, Lea Bogensperger, Julius Erbach, Nikolai Kalischek, Federico Tombari, Konrad Schindler, Dominik Narnhofer

CVPR 2026 IEEE/CVF Conference on Computer Vision and Pattern Recognition

We propose an improved MeanFlow training strategy that rapidly stabilizes instantaneous velocity before progressively emphasizing long-interval averages, enabling faster convergence and higher-quality one-step generation.

Restora-Flow: Mask-Guided Image Restoration with Flow Matching

Arnela Hadzic, Franz Thaler, Lea Bogensperger, Simon Johannes Joham, Martin Urschler

WACV 2026 IEEE/CVF Winter Conference on Applications of Computer Vision

We introduce Restora-Flow, a training-free method for mask-based inverse problems that guides flow matching sampling by a degradation mask and incorporates a trajectory correction mechanism to enforce consistency with degraded inputs.

2025

Energy Matching: Unifying Flow Matching and Energy-Based Models for Generative Modeling

Michal Balcerak, Tamaz Amiranashvili, Antonio Terpin, Suprosanna Shit, Lea Bogensperger, Sebastian Kaltenbach, Petros Koumoutsakos, Bjoern Menze

NeurIPS 2025 Conference on Neural Information Processing Systems

An energy matching framework is introduced, combining optimal transport paths far from the data manifold with an entropic energy term to explicitly capture data likelihood, enabling flexible priors and high-fidelity generation without auxiliary networks.

Flow Matching-Based Data Synthesis for Robust Anatomical Landmark Localization

Arnela Hadzic, Lea Bogensperger, Andrea Berghold, Martin Urschler

JBHI 2025 IEEE Journal of Biomedical and Health Informatics

A multi-channel generative approach based on flow matching synthesizes medical images paired with heatmaps, enabling robust data augmentation for anatomical landmark localization, especially with limited training data or occlusions.

2024

2023

2022

2021

Teaching